Development of colon delivery capsule. pressure controlled drug release system.
نویسندگان
چکیده
منابع مشابه
Development and in-vitro evaluation of a colon-specific controlled release drug delivery system.
The major challenges in targeting drug to various parts of the gastrointestinal tract include control of drug release with respect to its environment and transit time. These two variables should be taken into consideration in designing a rational colonic drug delivery system. To this end, a swelling matrix core containing pectin, hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose ...
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Over the past decades, the treatment of illness has been accomplished by administering drugs to the human body via various pharmaceutical dosage forms, like tablets. These traditional pharmaceutical products are still commonly seen today in the prescription and over-the-counter drug marketplace. To achieve and maintain the drug concentration in the body within the therapeutic range required for...
متن کاملSolid Sirolimus Self-microemulsifying Drug Delivery System: Development and Evaluation of Tablets with Sustained Release Property
The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...
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Controlled release drug delivery systems 1 are those dosage formulations designed to release an active ingredient at rates, which differ significantly from their corresponding conventional dosage forms. The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the delivery of the drug to a ti...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1995
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.10.49